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The Archives of the Balkan Medical Union Dynamics of histological changes in traumatized liver tissues in the absence of alcohol intoxication Author : Olena P.
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Liver injury is an important cause of death in patients with traumatic injuries. The objective of the study. To study the dynamics of changes in histological parameters of injured liver tissues in case of mechanical trauma, depending on the time of damages in the absence of alcohol intoxication. Materials and methods. We examined liver tissue of 52 individuals 38 men and 14 women aged years, who died at known and unknown time in the absence of alcohol in the blood in the Lugansk region of Ukraine.
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The cause of death was a mechanical trauma. The study was conducted by means of histological, histochemical methods, statistical analysis. Cure hpv fasting histological changes were observed in the area of injured liver tissue.
These changes directly depend on the time elapsed since the caused damage. Usage of the histological method was proved to be expedient for determining the time of injury, both in the cure hpv fasting liver injury and in combined injuries of the abdominal organs. This method allows to increase the objectivity of the results determining the time of cure hpv fasting. The study determined changes of histological parameters of liver tissue depending on the time of injury, time of death, presence of traumatic illness, which can help in solving the question on the injury duration.
The aim of the study. Dynamic vierme rotunde vierme rotunde of immunobiological and immunophenotypic parameters in the treatment of patients with NHL, and recognition of immunological remissions.
Material and cure hpv fasting. The retrospective study group consisted of patients, admitted between and in the Hematology Clinic of the Republic of Moldova Oncology Institute, with a morphologically confirmed diagnosis of NHL. We assessed the cure hpv fasting phenotypic line by indirect immunophenotyping and total concentration of immunoglobulin classes A, M, G according to treatment regimens applied to NHL patients.
NHL patients with both aggressive and non-aggressive primary variants after 3 cycles and 6 cycles presented a significant decrease in immunoglobulin A, M, and G indices, on average of 7. The burden of immunodeficiency and infectious diseases is rapidly increasing worldwide.
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Thus, it becomes necessary to find effective and affordable immunomodulatory drugs that may modify the response of the immune system.
To investigate ultramicroscopic changes that occur in parathyroid glands and thymus of male rats after cure hpv fasting of the immunomodulatory agent imunofan. Thirty-six WAG matured male rats were divided randomly into two groups.
The first group received imunofan in a dosage of 0. Rodents were sacrificed on the 3rd and 30th day after injection and specimens were dissected out and processed for electron microscopy.
The second group served as control and was provided 0.
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The results showed that imunofan exposure caused marked ultramicroscopic changes in parathyroid glands and thymus of rats. On the 3rd day after injection, the amount of the active chief cells significantly increases. A significantly increased number of secretory granules is recognized as the ultrastructural hallmark of chief cells change. Thymus in this term of imunofan administration showed no significant ultrastructural changes in comparison to control group.
On the 30th day after the administration, the examination revealed that all the glands of the experimental rats have big amounts of active cells with well-developed secretory apparatus. A cure hpv fasting amount of the secretory granules as the material might be excreted by exocytosis into the intercellular cure hpv fasting.
Electron microscopy of thymus revealed that imunofan injection causes changes in organ as a result of the activation of cell-mediated and antibody-mediated immunity on 30th day. Apparently, it also causes temporary delay of age-related thymic involution. HOLIAR Abstract Full Text Abstract : The objective of the study was to research the dynamics of changes in oxidative and reducing systems in the blood and tissues of the pancreas, lungs and liver during the development of acute necrotizing pancreatitis.
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The degree of oxidative modification of plasma proteins was assessed by the method of I. The content of malonic aldehyde in the erythrocytes was determined by the method of I. Stalna and T. The content of ceruloplasmin in the serum was studied by M.
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Revina method. The level of medium mass molecules was determined by the method of N. The oxidative modification of proteins in the tissues of the pancreas, liver and lungs was carried out using the histochemical method and original techniques. The development of acute necrotic pancreatitis in the experiment was characterized by an increase in the activity of lipids and proteins in the blood and the oxidative modification of proteins in pancreatocytes, hepatocytes and alveocytes, which is one of the leading mechanisms for their lesion.
The growth of the oxidative modification of proteins in the endothelial cells of the pancreas, liver and lungs cure hpv fasting the development of acute pancreatitis contributes to the occurrence of endothelial dysfunction, which is the leading factor in the secondary lesions of these organs.
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Considering the important role of lipoperoxidation and oxidative modification of proteins in the mechanisms of progression of acute necrotic pancreatitis, it is pathogenically grounded to develop new effective methods of systemic and local antioxidant and anti-proteolytic effects.
The experimental part of the work was performed on 16 white rats of the Wistar population. Internal organs and tissues were subjected to the study of the state of receptor binding parameters of labeled C1, C2 serotonin, a1, a2, ß-adreno, D2-dopamine and glucocorticoid type II receptor agonists and antagonists in various regions of the brain and liver.
The functional activity of the receptors was assessed by affinity and the number of binding sites and ligands. The study of the effect of sodium fluoride on the cure hpv fasting characteristics of the adrenoreceptors of the membrane fractions of liver cells and the cerebral cortex showed similar dynamic changes in the parameters of receptor binding of both a1-adreno- and ß1-adrenoreceptors.
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The effect of sodium fluoride was manifested vierme de mare a decrease in the affinity of the radioligand for a2-adrenoreceptors and an increase in the number cure hpv fasting binding sites for this type of receptors. Similar dynamics of the kinetic characteristics of a2-adrenoreceptors was found in the cerebellum.
The number of binding sites for ß1-adrenoreceptors increased, while their affinity for ligands decreased. In the brainstem, there was a decrease in the affinity of the D2-receptors for ligands and the number of binding sites. Under conditions of subtoxic effect of sodium fluoride on white rats, a decrease in the affinity of radioligands for C2-receptors and the number of their binding sites in the cerebral cortex was observed.
The results of the study show that under the conditions of the formation of fluoride intoxication, structural and functional disorders of the receptor apparatus occur, which confirms tratament de detoxifiere leading role in the development of this pathology of the state of biological membranes.
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Changes in the kinetic characteristics of adrenaline a1, a2, ß1serotonin C1, C2dopamine D2 and glucocorticoid receptors confirm the polytropic nature of the action of sodium fluoride on organs, systems and functions of the body.
Influence of melatonin on the activity of main enzymes of cori cycle in skeletal muscles, heart, liver and kidneys of alloxan-induced diabetic rats Author : Oleksandra Yu. Melatonin, a potent antioxidant agent, is essential for glucose homeostasis.
The objective of the cure hpv fasting was to determine the influence of melatonin on basal levels of glucose in blood, activities of glucosephosphatase in kidney and liver, pyruvate kinase in muscles and heart, content of glycogen in muscles and heart of rats with alloxan-induced diabetes. Melatonin injections caused normalization of the elevated serum glucose level in diabetic group of rats compared with basal glucose level before treatment.
Melatonin restored all these indexes back to normal level. These findings suggested that melatonin restored the events in Cori cycle by possible activation of glycolysis in skeletal and heart muscles and normalization of gluconeogenesis in liver and kidneys.
Dynamics of aldosterone, connective tissue reorganization and glucose level as markers for tuberculosis treatment effectiveness Author : Olga S. The study was performed on 84 patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis. Aldosterone, free and protein-bound hydroxyproline and glucose levels were measured in all patients.
There was an increase in this index during the first 2 months of treatment in both groups. Protein-bound hydroxyproline level was higher in group I by The level of aldosterone at the treatment onset was almost identical in both groups. After 2 months of treatment, its level decreased in both groups. However, after 2 months of treatment in group I, its index was lower than in group II by